The TLX1 Break Apart FISH Probe Kit is designed to detect rearrangements in the human TLX1 gene located on chromosome band 10q24.31.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other TLX1 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the TLX1 gene – also known as TCL3 or HOX11 – have been observed in acute lymphoblastic leukemia （ALL）, non-Hodgkin lymphoma （NHL） and other malignancies.
