The FIP1L1-CHIC2-PDGFRA Tri-color FISH Probe Kit is designed to detect rearrangements involving the human FIP1L1, CHIC2 and PDGFRA genes located on chromosome band 4q12.
Rearrangements between the FIP1L1 and PDGFRA genes with an interstitial deletion at the CHIC2 gene region have been observed in diverse eosinophilia-associated hematologic disorders like hyperseosinophilic syndrome （HES）, systemic mastocytosis （SM） and chronic eosinophilic leukemia （CEL）.
