The MECOM-RUNX1 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human MECOM and RUNX1 genes located on chromosome bands 3q26.2 and 21q22.12, respectively.
Fusion of MECOM – also known as EVI1, MDS1, PRDM3, MDS1-EVI1 or AML1-EVI-1 – with the RUNX1 gene – also known as AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1 or PEBP2aB – has been observed in chronic myelogenous leukemia （CML）, myelodysplastic syndrome （MDS）, acute myeloid leukemia （AML） and other malignancies.
