The TP53/CD37 FISH Probe Kit is designed to detect rearrangements involving the human TP53 and CD37 genes located on chromosome bands 17p13.1 and 19q13.33, respectively.
Abnormal expression of the TP53 gene – also known as P53, BCC7, LFS1 or TRP53 – has been observed in a large number of tumor types and some other conditions.
The CD37 gene – also called GP52-40 or TSPAN26 – is upregulated in Burkitt's lymphoma and other B-cell malignancies, and expressed in a number of solid tumor types as well.
