The SEC63/SMAD6 FISH Probe Kit is designed to detect the human SEC63 gene located on chromosome band 6q21, and the SMAD6 gene on chromosome band 15q22.31.
Abnormal expression of the SEC63 gene – also known as ERdj2, SEC63L, DNAJC23 or PRO2507 – has been observed in lymphoid malignancies such as chronic lympocytic leukemia （CLL） and other cancers.
Abnormalities in SMAD6 – also known as AOVD2, MADH6, MADH7 or HsT17432 – are associated with cardiac valve defects and developmental deficiencies.
SMAD6 expression has been reported to promote cell survival in lung cancer and other tumor types.
