The ETV4 Break Apart FISH Probe Kit is designed to detect rearrangements in the human ETV4 gene located on chromosome band 17q21.31.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other ETV4 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the ETV4 gene – also known as E1AF, PEA3, E1A-F or PEAS3 – have been observed in melanoma, breast, lung, prostate and other cancers.
