The PTPRT/CCP20 FISH Probe Kit is designed to detect the human PTPRT gene located on chromosome band 20q12, along with the number of chromosome 20 copies per cell.
Normal function of the PTPRT gene product - also called RPTPrho, PTPrho or PTPρ – is frequently lost in human colon cancers.
The gene likely serves as a tumor suppressor gene in colorectal, lung, skin and stomach cancers.
The locus is also deleted in some acute leukemias and other myeloproliferative disorders.
