The TCL1A Break Apart FISH Probe Kit is designed to detect rearrangements in the human TCL1A gene located on chromosome band 14q32.13.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other TCL1A aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the TCL1A gene – also known as TCL1 – have been observed in T-cell leukemias and other malignancies.
