The RPN1-MECOM Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human RPN1 and MECOM genes located on chromosome bands 3q21.3 and 3q26.2, respectively.
Rearrangements between the two genes, the RPN1 gene – also known as OST1 or RBPH1 – and the MECOM gene – also called EVI1, MDS1, PRDM3, MDS1-EVI1 or AML1-EVI-1, have been observed in acute myeloid leukemias （AML） and other malignancies.
