The PDGFRA Break Apart FISH Probe Kit is designed to detect rearrangements in the human PDGFRA gene located on chromosome band 4q12.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other PDGFRA aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the PDGFRA gene – also known as CD140A, PDGFR2, PDGFR-2 or RHEPDGFRA – have been observed in gastrointestinal stromal tumors （GIST）, lung adenocarcinoma and other hematologic and solid tissue disorders.
