The MECOM Break Apart FISH Probe Kit is designed to detect rearrangements in the human MECOM locus located on chromosome band 3q26.2.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other MECOM aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the MECOM gene – also known as EVI1, MDS1, PRDM3, MDS1-EVI1 or AML1-EVI-1 – have been observed in acute and chronic myelogenous leukemias, Myelodysplastic Syndrome （MDS） and other malignancies.
