The COL1A1 Break Apart FISH Probe Kit is designed to detect rearrangements in the human COL1A1 gene located on chromosome band 17q21.33.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other COL1A1 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the COL1A1 gene – also known as OI4 – have been observed in dermatofibrosarcoma protuberans （DFSP） and some other tumor types.
