The DDIT3 Break Apart FISH Probe Kit is designed to detect rearrangements in the human DDIT3 gene located on chromosome band 12q13.3.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other DDIT3 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the DDIT3 gene – also known as CHOP, CEBPZ, CHOP10, CHOP-10, GADD153 – have been observed in myxoid liposarcome and other malignancies.
