The EWSR1 Break Apart FISH Probe Kit is designed to detect rearrangements in the human EWSR1 gene located on chromosome band 22q12.2.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other EWSR1 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the EWSR1 gene – also known as EWS or bK984G1.4 – have been observed in Ewing's sarcoma and in numerous neuroectodermal and other tumor types.
