The ROS1 Break Apart FISH Probe Kit is designed to detect rearrangements in the human ROS1 gene located on chromosome band 6q22.1.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other ROS1 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the ROS1 gene – also known as ROS, MCF3 or c-ros-1 – have been observed in lung adenocarcinoma and various other tumor types.
