The CARS Break Apart FISH Probe Kit is designed to detect rearrangements in the human CARS gene located on chromosome band 11p15.4.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other CARS aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the CARS gene – also known as CARS1, CYSRS or MGC：11246 – have been observed in inflammatory myofibroblastic tumors （IMT） and several other tumor types.
