The TFG Break Apart FISH Probe Kit is designed to detect rearrangements in the human TFG gene located on chromosome band 3q12.2.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other TFG aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the TFG gene – also known as TF6, HMSNP, SPG57 or TRKT3 – have been observed in anaplastic large cell lymphoma, thyroid papillary carcinoma, extraskeletal myxoid chondrosarcoma, renal cell carcinoma and other cancer types.
