The ALK Break Apart FISH Probe Kit is designed to detect rearrangements in the human ALK gene located on chromosome band 2p23.2.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other ALK aberrations such as deletions or amplifications.
Initially discovered in anaplastic large cell lymphoma （ACLC）, rearrangements of ALK – also known as CD246 or NBLST3 – have since been found in many types of malignancies, including B- and T-cell lymphomas, plasmacytomas, neuroblastoma, esophageal, breast, kidney, colon thyroid, lung and other cancers.
A significant percentage of non-small cell lung cancer （NSCLC） cases harbor ALK gene abnormalities.
