83-2272-32　［受注停止］KRIBIOLISA Cinrebafusp alfa ELISA 1 x 96 wells　KBI1754

特徴

• Description：ELISA for the detection of bispecific antibody Cinrebafusp alfa in human serum and plasma.
• Lead time for this kit is 5 weeks.
• About the kit： - Uses anti-idiotypic monoclonal antibodies sourced from our vendor partner in the US, which ensures higher specificity, and low cross reactivity.
• - Recovery rates are between 85 - 115％ - Validated as per US FDA guidelines for Bioassays - Developed using the innovator drug as calibrator - Shelf life： 1 year.Cinrebafusp alfa is a bivalent, bispecific fusion protein comprised of an anti-human epidermal growth factor receptor （HER2） monoclonal antibody linked to a CD137-targeting anticalin.
• Upon administration of cinrebafusp alfa, CD137 clustering is promoted by bridging CD137-positive T cells with HER2-positive tumor cells, leading to the recruitment of tumor antigen-specific cytotoxic T-lymphocytes （CTLs）, resulting in potent CTL-mediated lysis of HER2-expressing tumor cells.
• Currently, cinrebafusp alfa is being studied as a combination therapy for various HER2 tumors.