83-2271-79　［受注停止］KRISHZYME Heparin Factor IIa Assay Kit 100 tests / 1 kit　KBBA03S

特徴

• Description：Chromogenic assay for testing Heparins （UFH） in purified systems by measurement of Factor IIa
• inhibition, in compliance with EP Pharmacopoeia.
• About the kit：
• - Uses anti-idiotypic antibodies sourced from our vendor partner in the US, which ensures higher specificity, and low cross reactivity.
• - Recovery rates are between 85 - 115％
• - Ready to use with a standard protocol with break-apart pre-coated wells
• - Validated as per US FDA guidelines for Bioassays
• - Optimized for matrix effects to ensure higher sensitivity.
• - Shelf life： 1 year
• The inhibitory effect of Anti-Thrombin III （AT-III） on thrombin （Factor IIa） and other coagulation serine proteases in
• plasma is increased several thousand-fold by heparin.
• This inhibition accounts for the anticoagulant effect of
• heparin.
• The quantitative determination of heparin levels by the measurement of their Anti-IIa activity is a
• necessary tool for monitoring treatment efficacy.
• Unfractionated heparin （UFH） catalyzes both reactions equally.
• The Factor IIa inhibition test is the most useful
• assay covering the widest variety of heparin preparations.
• In the assay, the rate of Factor IIa inhibition is directly
• proportional to the heparin concentration since both Factor IIa and AT-III are in excess.
• The residual factor IIa
• activity is inversely proportional to the heparin concentration.