83-1198-22　Recombinant Human CRHBP （C-His） 10ug　BP273-10ug

特徴

• 背景：Corticotropin-Releasing Factor-Binding Protein （CRHBP） is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitaryadrenal stimulation in pregnancy. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues. Although CRF-BP concentration in the human peripheral circulation is normally low, it increases throughout pregnancy and fall back rapidly after parturition

仕様

• サイズ：10ug
• 種由来：Human
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：Tyr25-Leu322
• FormulationSupplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, pH7.5
• Accession 番号：P24387
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