83-1174-27　Recombinant Human PSD95/Disks large homolog 4/DLG4（N-His） 1mg　BP196-1mg

特徴

• 背景：Postsynaptic density protein 95 （PSD-95）, also known as disks large homolog 4（DLG4） is a cell membrane protein that is a member of the membrane-associated guanylate kinase （MAGUK） family. DLG4 is recruited into the same NMDA receptor and potassium channel clusters as PSD-93. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the best-studied member of the MAGUK-family of PDZ domain-containing proteins. It is nearly exclusively located in the post-synaptic density of neurons and plays a role in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. DLG4 is also involved in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation. A recent study showed that clinical manifestations associated with DLG4 overlapping with those found in other neurodevelopmental disorders of synaptic dysfunction.

仕様

• サイズ：1mg
• 種由来：Human
• 発現宿主：E.coli
• エンドトキシン：Less than 1 EU/ug
• タグ：N-6His
• Target Sequence：Met1-Leu724
• FormulationLyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Accession 番号：P78352
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

• 【試薬に関するお問合せ】
• アズワン株式会社 試薬・プロセス材料グループ
• TEL：06-6447-8641
• FAX：06-6447-8642
• E-mail：[email protected]