83-1173-86　Recombinant Human IL-1R1 （C-His） 500ug　BP234-500ug

特徴

• 背景：Interleukin 1 receptor, type I （IL-1R1） is an interleukin receptor that is a member of the interleukin-1 receptor family. IL-1R1 is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1R1 mediates numerous cytokine-induced immune and inflammatory responses. It binds to interleukin-1 along with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binding of IL-1R1 to antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

仕様

• サイズ：500ug
• 種由来：Human
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：Asp21-Pro330
• FormulationLyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Accession 番号：P14778
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