83-1173-74　Recombinant Mouse Apolipoprotein E/ApoE （C-His） 500ug　BP205-500ug

特徴

• 背景：Apolipoprotein E （ApoE） is a glycoprotein that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. ApoE can be synthesized by the liver and intestinally synthesized chylomicrons. ApoE mediates high-affinity binding of chylomicrons and very low density lipoprotein （VLDL） particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol-rich particles in the plasma. ApoE plays an essential role in the formation of plasma lipoproteins and is involved in their production, conversion and clearance. ApoE is also a constituent of a subclass of high density of lipoproteins （HDL） involved in cholesterol transport. More recently, ApoE has been studied for its role in several biological processes not directly related to lipoprotein transport, including Alzheimer's disease, immunoregulation, and cognition. Though the exact mechanisms remain to be clarified, isoform 4 of APOE, has been associated with increased calcium ion levels and apoptosis following mechanical injury.

仕様

• サイズ：500ug
• 種由来：Mouse
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：Glu19-Gln311
• FormulationLyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 0.1％Tween 80, 10％ trehalose, pH 7.4
• Accession 番号：P08226
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

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