83-1173-06　Recombinant Mouse IL-1RA 10ug　BP197-10ug

特徴

• 背景：Interleukin-1 receptor antagonist protein （IL-1RA）, also known as IL1 inhibitor, is a member of the interleukin 1 cytokine family. IL-1RA inhibits the activities of interleukin 1 alpha （IL1A） and interleukin 1 beta （IL1B）, and is involved in a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids （aa） protein with a 26 aa signal peptide. Mouse IL-1RA protein shares 26％ and 19％ identity with its homologs IL-1 beta and IL-1 alpha, respectively. IL-1RA can suppress the activity of interleukin-1 by binding to receptor IL1R1 and averting its association with the coreceptor IL1RAP for signaling. In recent studies, recombinant human IL-1RA proteins are used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.

仕様

• サイズ：10ug
• 種由来：Mouse
• 発現宿主：E.coli
• エンドトキシン：Less than 1 EU/ug
• タグ：tag free
• Target Sequence：Arg27-Gln178
• FormulationLyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4
• Accession 番号：P25085
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