83-1172-95　Recombinant Human TREM-1 （C-His） 10ug　BP189-10ug

特徴

• 背景：TREM1 （triggering receptor expressed on myeloid cells） is a type I transmembrane protein with a single Ig-like domain. TREM1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. Although its natural ligand has not been found, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein （MCP）-1. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. It has been demonstrated that TREM1 plays an important role in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock.

仕様

• サイズ：10ug
• 種由来：Human
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：Ala21-Arg200
• FormulationLyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.2
• Accession 番号：Q9NP99
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