83-1172-13　Recombinant Human NKG2-A/NKG2-B Type II Integral Membrane Protein（N-His） 10ug　BP029-10ug

特徴

• 背景：NKG2-A/NKG2-B Type II Integral Membrane Protein contains 1 C-type lectin domain and is a member of the killer cell lectin-like receptor family. The killer cell lectin-like receptor family is a group of transmembrane proteins mainly expressed in NK cells. Members of this proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. NKG2 is expressed only in NK-cells, but not in T-cells or B-cells. Studies showed that NKG2 represents a family of related cDNA clones, designated NKG2A, NKG2B, NKG2C, and NKG2D, which encode type II integral membrane proteins （extracellular C-terminus） containing a C-type lectin domain. NKG2 acts as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. NKG2A and NKG2B have been given the designation CD159a in the nomenclature of CD antigens. The increased expression of NKG2A in tumor infiltrating NK cells is emerging as a contributor in determining the poor prognosis of hepatocellular, lung or other carcinomas and in some cases may be a predictive factor of tumor metastasis

仕様

• サイズ：10ug
• 種由来：Human
• 発現宿主：Human Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：N-8His
• Target Sequence：Arg100-Leu233
• FormulationSupplied as a 0.2 um filtered solution of PB, pH7.4
• Accession 番号：P26715
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