83-1171-37　Recombinant Human BMP-7 （C-hFc） 500ug　BP1045-500ug

特徴

• 背景：Bone morphogenetic protein 7 （BMP-7）, also known as osteogenic protein 1 （OP-1）, is a widely expressed TGF-beta superfamily member with important functions during embryogenesis, in the adult, and in disease （1, 2）. Human BMP-7 is synthesized with a 29 amino acid （aa） signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain （3, 4）. The growth factor domain of human BMP-7 shares 98％ aa sequence identity with mouse and rat BMP-7. The BMP-7 propeptide is cleaved intracellularly but remains in association with the growth factor domain. BMP-7 is subsequently secreted as a tetramer that consists of two propeptides and two disulfide-linked growth factor domains （5, 6）. Mature BMP-7 can also form disulfide-linked heterodimers with BMP-2 or BMP-4, complexes that show increased potency and range of activity compared to BMP-7 homodimers （7-9）. The presence of the propeptides in the BMP-7 tetramer does not diminish the bioactivity of the growth factor domains （6）. Secreted BMP-7 is immobilized in the extracellular matrix as a result of interactions between the propeptide and matrix Fibrillin （5）. BMP-7 exerts its biological effects through the type 2 receptors Activin RIIA, Activin RIIB, and BMPR-II and the type 1 receptors Activin RIA, BMPR-IA, and BMPR-IB （2, 6）. BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development （10, 11）, inhibits the branching of prostate epithelium （12）, and antagonizes epithelial-mesenchymal transition （EMT） （13-15）. In pathological conditions, BMP-7 inhibits tumor growth and metastasis （14）, ameliorates fibrotic damage in nephritis （13）, and promotes neuroregeneration following brain ischemia （16）.