83-1171-13　Recombinant Human BMP-2 （C-His） 50ug　BP1043-50ug

特徴

• 背景：Bone morphogenetic protein 2 （BMP-2） is a member of the BMP subgroup of the TGF-β superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor （Activin RI, BMP-RIA or BMP-RIB） and a type II receptor （BMP-RII or Activin RIIB）. BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.

仕様

• サイズ：50ug
• 種由来：Human
• 発現宿主：E. coli
• エンドトキシン：Less than 1 EU/ug
• タグ：C-His
• Target Sequence：Arg289-Arg396
• FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Accession 番号：NP_001191.1
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