83-1168-63　Biotinylated Recombinant Mouse MerTK （C-hFc） 250ug　BP1108-250ug

特徴

• 背景：Tyrosine-protein kinase Mer（MERTK） is a member of the TYRO3/AXL/MER （TAM） receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type （immunoglobulin-like） domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium （RPE） as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors （TLRs）-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

仕様

• サイズ：250ug
• 種由来：Mouse
• 発現宿主：Human Cells
• エンドトキシン：Less than 1 EU/ug
• タグ：C-Human Fc
• Target Sequence：Glu23 - Phe498
• FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Accession 番号：Q12866-1
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