83-1167-35　Recombinant Human CD3E （C-His） 10ug　BP144-10ug

特徴

• 背景：CD3 epsilon （T-Cell Surface Glycoprotein CD3 Epsilon） is a type I transmembrane protein that belongs to the immunoglobulin superfamily. There are four CD3 proteins： CD3 delta, CD3 epsilon, CD3 gamma, and CD3 zeta. All CD3 proteins contain ITAM （Immunoreceptor Tyrosine-based Activation Motifs） in the cytoplasmic tail, which becomes phosphorylated by Src family protein tyrosine kinases LCK and FYN upon TCR engagement. CD3 proteins form heterodimers of CD3 delta/CD3 epsilon and CD3 gamma /CD3 epsilon, which bind to TCR and form trimeric TCR alpha /CD3 epsilon /CD3 gamma and TCR beta /CD3 gamma /CD3 epsilon. The resulting heterohexamer further associates with CD3 zeta homodimer and forms TCR/CD3 signaling complex. This complex is involved in coupling antigen recognition to several intracellular signal-transduction pathways. CD3 epsilon plays a critical role in adaptive immune response. Defects in CD3 epsilon lead to SCID （severe combined immunodeficiency）.

仕様

• サイズ：10ug
• 種由来：Human
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：Asp23-Asp126
• FormulationLyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Accession 番号：P07766
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