83-1167-13　Recombinant Mouse TREM-1 （C-His） 50ug　BP130-50ug

特徴

• 背景：Triggering Receptor Expressed on Myeloid Cells 1, known as TREM-1, is a transmembrane protein with a single Ig-like domain. TREM-1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. TREM-1 associates with the adapter protein, DAP12, to deliver an activating signal, which stimulates neutrophil and monocyte-mediated inflammatory responses. TREM-1 also triggers the release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is an amplifier of inflammatory responses that are triggered by bacterial and fungal infections and are a crucial mediator of septic shock.

仕様

• サイズ：50ug
• 種由来：Mouse
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：Ala21-Ser202
• FormulationLyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Accession 番号：Q9JKE2
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