83-1166-87　Recombinant Human Collagen a-1（VIII） Chain/COL8A1 （C-6His） 500ug　BP030-500ug

特徴

• 背景：Collagen alpha-1（VIII） chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the Descemet's membrane （basement membrane） of corneal endothelial cells. COL8A1 forms homotrimers or heterotrimers in association with alpha 2（VIII） type collagens. Four homotrimers can form a tetrahedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 is mainly expressed in the subendothelium of large blood vessels. The expression level can be up-regulated during vascular injury, in atherosclerosis and in diabetes. COL8A1 is necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

仕様

• サイズ：500ug
• 種由来：Human
• 発現宿主：Human Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：Gly28-Met744
• FormulationSupplied as a 0.2 um filtered solution of 20mM PB,150mM NaCl, PH7.2
• Accession 番号：P27658
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