83-1165-99　Recombinant Human Interleukin-7/IL-7 （C-His） 50ug　BP086-50ug

特徴

• 背景：Interleukin 7 （IL-7） is a cytokine that belongs to hemopoietin family. IL-7 is secreted by stromal cells in the red marrow and thymus, and can also be produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, except for lymphocytes. IL-7 stimulates the differentiation of multipotent hematopoietic stem cells into lymphoid progenitor cells. It also induces the proliferation of all cells in the lymphoid lineage （B cells, T cells and NK cells）. IL-7 and the hepatocyte growth factor （HGF） together form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. IL-7 signals via IL-7 receptor （IL7R） activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. IL-7 has recently been examined in clinical studies as an immunotherapy agent for various malignancies and during HIV infection. Besides, IL-7 could be beneficial in improving immune recovery after allogenic stem cell transplant.

仕様

• サイズ：50ug
• 種由来：Human
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：D26-H177
• FormulationLyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Accession 番号：P13232
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