83-1165-50　Recombinant Human Siglec-2/CD22 （C-His） 50ug　BP063-50ug

特徴

• 背景：B-cell receptor CD22, also known as Siglec-2, is a member of the immunoglobulin superfamily, SIGLEC family of lectins. CD22 is expressed by B-lymphocytes and can mediate B-cell B-cell interactions, as well as the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. As an inhibitory coreceptor of the B-cell receptor （BCR）, CD22 plays a central role in establishing signaling thresholds for B-cell activation. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.

仕様

• サイズ：50ug
• 種由来：Human
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-10His
• Target Sequence：D20-R687
• FormulationLyophilized from a 0.2 um filtered solution of PBS, pH 7.4
• Accession 番号：P20273
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