83-1165-48　Recombinant Mouse Interleukin-11/IL-11 （N-His） 50ug　BP062-50ug

特徴

• 背景：Interleukin 11 （IL-11） is a pleiotropic cytokine that belongs to the IL-6 family. As a thrombopoietic growth factor, IL-11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. IL-11 also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2, it activates a signaling cascade that promotes cell proliferation. The signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. IL-11 is found to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis.

仕様

• サイズ：50ug
• 種由来：Mouse
• 発現宿主：E. coli
• エンドトキシン：Less than 0.1 ng/ug （1 EU/ug）
• タグ：N-6His
• Target Sequence：G23-L199
• FormulationSupplied as a 0.2 um filtered solution of 2umM Tris-HCl, 30umM NaCl, 10％ Glycerol, pH8.0.
• Accession 番号：P47873
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