83-1165-28　Recombinant Cyno NKG2A ＆ CD94 Heterodimer 50ug　BP050-50ug

特徴

• 背景：NKG2-A contains C-type lectin domain and belongs to the killer cell lectin-like receptor （KLR） family. KLR family is a group of transmembrane proteins preferentially expressed in natural killer （NK） cells. NK cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94, also known as killer cell lectin-like receptor subfamily D member 1 （KLRD1）, is expressed on the surface of NK cells in the innate immune system. CD94 plays a role as a receptor for the recognition of MHC class I Human Leukocyte Antigen （HLA）-E molecules by NK cells and some cytotoxic T-cells. CD94 can form disulfide-bonded heterodimer with NKG2A on the surface of NK cells. The CD94/NKG2A complex interacts with HLA-E on target cells and inhibit the cytotoxic activity of NK cells to prevent cell lysis.

仕様

• サイズ：50ug
• 種由来：Cynomolgus
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：N-8His＆N-FLAG
• Target Sequence：Lys100-Leu233; Ser34-Ile179
• FormulationLyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Accession 番号：Q9MZJ2 ＆ Q9MZK9
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