83-1164-82　Recombinant Human Interleukin-10/IL-10 （C-His） 500ug　BP008-500ug

特徴

• 背景：Interleukin-10 （IL-10）, also known as cytokine synthesis inhibitory factor （CSIF）, is a secreted protein that belongs to the IL-10 family. IL-10 is secreted by various mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. As a major immune regulatory cytokine, IL-10 has profound anti-inflammatory functions on many cells of the immune system, limiting excessive tissue disruption caused by inflammation. Studies showed that IL-10 provides a feedback loop to limit the effector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10 receptor （IL-10R） to activate STAT3. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations

仕様

• サイズ：500ug
• 種由来：Human
• 発現宿主：Human 293 Cells
• エンドトキシン：Less than 0.1 EU/ug
• タグ：C-6His
• Target Sequence：Ser19-Asn178
• FormulationLyophilized from a 0.2 um filtered solution of PBS, pH 7.2
• Accession 番号：P22301
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